02 December 2015

NOTICIA 2

ESTA ES LA 2ª NOTICIA

La casa, construida hacia finales del siglo XVIII, consta de 2 plantas y “sabaya” o aprovechamiento bajo cubierta con un total de 6 habitaciones rústicas y sencillas, todas ellas con baño, y una zona común con fogaril y comedor.La casa, construida hacia finales del siglo XVIII, consta de 2 plantas y “sabaya” o aprovechamiento bajo cubierta con un total de 6 habitaciones rústicas y sencillas, todas ellas con baño, y una zona común con fogaril y comedor.La casa, construida hacia finales del siglo XVIII, consta de 2 plantas y “sabaya” o aprovechamiento bajo cubierta con un total de 6 habitaciones rústicas y sencillas, todas ellas con baño, y una zona común con fogaril y comedor.La casa, construida hacia finales del siglo XVIII, consta de 2 plantas y “sabaya” o aprovechamiento bajo cubierta con un total de 6 habitaciones rústicas y sencillas, todas ellas con baño, y una zona común con fogaril y comedor.La casa, construida hacia finales del siglo XVIII, consta de 2 plantas y “sabaya” o aprovechamiento bajo cubierta con un total de 6 habitaciones rústicas y sencillas, todas ellas con baño, y una zona común con fogaril y comedor.La casa, construida hacia finales del siglo XVIII, consta de 2 plantas y “sabaya” o aprovechamiento bajo cubierta con un total de 6 habitaciones rústicas y sencillas, todas ellas con baño, y una zona común con fogaril y comedor.

 

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    Performance-Enhancing Drugs



    # Performance-Enhancing Drugs

    ## Introduction
    Performance-enhancing drugs (PEDs) are substances used to improve
    physical and mental performance. They are widely sought after by athletes,
    bodybuilders, and individuals looking to enhance their capabilities beyond natural limits.
    This article explores the various types of PEDs, their prevalence, effects, risks, and clinical approach to addressing their
    use.

    ## Objectives
    To provide an overview of PEDs, their categories, physiologic effects, and the associated
    risks. To highlight the importance of education and clinical vigilance in identifying and managing PED use.



    ## Educational Gap
    There is a significant gap in understanding the types of PEDs,
    their mechanisms, and the long-term consequences of their use.

    Clinicians often lack comprehensive knowledge about the latest developments
    in PEDs, making it challenging to effectively address their impact.


    ## Performance-Enhancing Drugs

    ### Anabolic Agents
    Anabolic agents are designed to increase muscle synthesis and reduce fat storage.

    Examples include:
    - **Anabolic-Androgenic Steroids (AAS)**: Synthetic derivatives of testosterone that promote muscle growth and strength.

    - **Stimulants**: Caffeine, amphetamines, and other compounds that enhance alertness and energy.


    ### Steroid Precursors
    These are substances that can be metabolized into anabolic steroids.
    Examples include androstenedione and DHEA.

    ### Nutritional Supplements
    Highly purified products intended to enhance performance through
    physiological means, such as creatine and β-hydroxyβ-methylbutyrate (GH Bash).


    ## Epidemiology and Risk Factors
    The use of PEDs is prevalent in competitive sports, with rates varying by
    region and sport. Risk factors include:
    - Pressure to perform in sports or professions.
    - Desire for body image enhancement.
    - Availability and accessibility of these substances.


    ## Physiologic Effects
    PEDs can lead to both beneficial and harmful effects:

    - **Muscle Growth**: Promotes hypertrophy and strength.


    - **Performance Enhancement**: Improved endurance, speed, and energy levels.

    - **Adverse Effects**: Liver damage, hormonal
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    ## Prevalence of Use
    Surveys indicate that up to 10-20% of athletes use PEDs.
    The misuse is higher in individual sports compared to team sports.


    ## Administration
    PEDs are often administered in cycles, with the goal
    of avoiding detection. Methods include oral, intravenous, and
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    ## Testing
    Modern testing methods include urine and blood tests for detecting
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    ## Adverse Effects
    Long-term use can result in severe health consequences, including:
    - Liver damage from oral steroids.
    - Cardiac arrhythmias from stimulants.
    - Infertility and hormonal imbalances from exogenous hormone use.


    ## Steroid Precursors
    These compounds are often used to avoid the negative side effects of AAS while
    maintaining performance benefits.

    ## Nutritional Supplements
    These products are generally considered safe
    but can be misused to mimic PED effects.

    ## History
    The use of Performance-Enhancing Drugs dates back to ancient times, with early references in Greek
    culture and the development of anabolic steroids in the mid-20th century.


    ## Clinical Approach
    ### Physical Examination
    - Look for signs of muscle wasting or fat accumulation.
    - Assess for potential side effects like acne, hair loss, and hypertension.

    ### Anticipatory Guidance
    Educate patients on the risks and potential legal consequences
    of PED use. Emphasize natural performance enhancement through diet, training, and recovery.


    ## Summary
    Performance-Enhancing Drugs offer temporary gains in performance but
    come with significant health risks. Clinicians must stay informed about new PEDs and their effects to provide effective guidance.
    Collaborating with athletes and educators can help reduce the misuse of these
    substances.

    ## Glossary
    - **Anabolic Agents**: Substances that promote muscle growth
    and fat loss.
    - **Steroid Precursors**: Metabolites that can be converted
    into anabolic steroids.
    - **Nutritional Supplements**: High-purity products designed
    to enhance performance.

    ## Footnotes
    1. National Institute on Drug Abuse (NIDA) provides resources on drug abuse and performance-enhancing substances.

    2. International Olympic Committee (IOC) guidelines outline
    testing policies for PEDs in sports.

    ## Suggested Reading
    - "Performance Enhancing Substances" by World Anti-Doping Agency (WADA).

    - "The Use of Anabolic Steroids in Athletes" by National Institute on Drug Abuse.


    ## References
    1. World Anti-Doping Agency. (2019). *The Use of Doping Agents: A Review*.


    2. National Institute on Drug Abuse. (2020). *Performance Enhancing
    Substances*.

    ## ACTIONS
    - **PERMALINK**: Link to the article or resource.
    - **RESOURCES**: Links to relevant databases and organizations, such as
    NCBI and WADA.
    - **Similar Articles**: A list of related articles on the
    topic.
    - **Cited by other articles**: References where this article is cited.



    ## Links to NCBI Databases
    - NCBI Database Link(https://www.ncbi.nlm.nih.gov/)

    ## Cite
    For citing this article, use the appropriate citation style (e.g.,
    APA, MLA).

    ## Add to Collections
    If applicable, add this article to a collection or list of resources.

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