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  In early April, when the dust settled after mass firings across HHS, workers in NCI’s communications office were relieved they still had their jobs.
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  It didn’t last. A month later, HHS fired nearly all of them, three former workers said. Combined with retirements and other departures, a skeleton crew of six or seven remain of about 75 people. “We were all completely blindsided,” a fired worker said. NCI leadership “had no idea that this was happening.”
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  As a result, websites, newsletters, and other resources for patients and doctors about the latest evidence in cancer treatment aren’t being updated. They include Cancer.gov and NCI’s widely used Physician Data Query, which compile research findings that doctors turn to when caring for cancer patients.
  
  Gary Kreps, founding director of the Center for Health and Risk Communication at George Mason University, said he relied on Physician Data Query when his father was diagnosed with advanced stomach cancer, taking PDQ printouts when he met with his dad’s doctors. “It made a huge difference,” Kreps said. “He ended up living, like, another three years” — longer than expected — “and enjoyed the rest of his life.”
  
  As of May 30, banners at the top of the Cancer.gov and PDQ websites said, “Due to HHS restructuring and reduction in workforce efforts, the information on this website may not be up to date and pages will indicate as such.” The banners are gone, but neither website was being updated, according to a fired worker with knowledge of the situation.
  
  Outdated PDQ information is “really very dangerous,” Kreps said.
  
  Wiping out NCI’s communications staff makes it harder to share complex and ever-changing information that doctors and patients need, said Peter Garrett, who headed NCI’s communications before retiring in May. Garrett said he left because of concerns about political interference.
  
  “The science isn’t finished until it’s communicated,” he said. “Without the government playing that role, who’s going to step in?”
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  Monday, 21 July 2025 22:27

  High testosterone levels may also occur in less
  serious conditions. For example, congenital adrenal hyperplasia, which can have an effect on women and men, is a rare however natural cause
  for elevated testosterone production. For example, athletes and bodybuilders sometimes use anabolic steroids to improve athletic performance and construct muscle mass.
  
  High ranges of testosterone in female infants might result in enlargement of their clitoris that can look nearly like
  a penis. It also can result in precocious (early) puberty, which is when puberty begins before the age of eight.
  If an adult male’s testosterone levels are under 300 ng/dL,
  a doctor might do a workup to find out the cause of low testosterone, in accordance with the American Urological Association.
  "Anabolic" refers to muscle building, and "androgenic" refers to increased male intercourse characteristics.
  If your testosterone ranges are extremely excessive, your doctor might order other checks to
  find out the cause. Abnormally excessive levels of testosterone
  might be the outcome of an adrenal gland dysfunction, or even most cancers of the testes.
  Injury to the testicles and cancer remedies such as chemotherapy or radiation can negatively have an effect on testosterone manufacturing.
  Whereas testosterone production naturally tapers off as a man ages,
  different factors can cause hormone levels to drop.
  
  Exercising frequently, getting enough sleep, and eating a nutritious food regimen may help.
  However generally, way of life adjustments alone
  are sufficient to extend testosterone ranges. Some males use testosterone propionate
  or other types of synthetic testosterone to assist build muscle.
  This apply could be effective within the short-term, but it can trigger many health issues in the long run due to suppressing the body’s natural testosterone production. Testosterone propionate
  has a half-life of roughly 4 and a half days, which means half of it's eliminated
  from the body in that time.
  Nettle Root may help improve the quantity of free testosterone in the blood, which may help maximize bodily efficiency and gains.
  
  Some people report feeling nauseous whereas consuming
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  Chemotherapy and radiation remedy could cause testosterone deficiency.
  
  
  Exercise, especially cardiovascular train, can contribute
  to weight loss, which may help to increase levels of testosterone.
  The ranges of testosterone in your physique are continually
  altering in response to your body’s wants. However,
  the general level of testosterone in your physique changes all
  through your lifetime as well. Your adrenal glands,
  found above your kidneys, also produce a small quantity of
  hormones your body can remodel into testosterone. Most of the testosterone in your body is regulated
  by the hypothalamus (an space of the mind that
  produces various hormones), pituitary glands, and testes.
  
  Verify with your physician right away when you have stomach ache, confusion, constipation, depression, dry mouth, elevated urination, loss of urge
  for food, metallic taste, or muscle weakness. This drugs shouldn't
  be used by female patients, especially if pregnant
  or breastfeeding. Testosterone might cause birth defects if a pregnant
  particular person is obtainable in contact with the medication. If a being pregnant happens while you're using this drugs,
  tell your doctor right away. If you’re experiencing symptoms of low
  testosterone, similar to a lower in sex drive and sizzling flashes,
  discuss to a healthcare provider.
  The invention of artificial testosterone marked a
  major breakthrough since it made hormone substitute extra profitable and cost-efficient.
  Testosterone propionate was first synthesized and used medically in the Nineteen Thirties — only a few
  years after the invention of the hormone testosterone itself.
  It’s administered via an intramuscular injection (a
  small needle going right into a muscle). Testosterone propionate is also typically used recreationally
  to stimulate muscle growth, primarily amongst bodybuilders and athletes.
  All content on this website, including dictionary, thesaurus, literature, geography, and other reference
  information is for informational functions only.
  This data shouldn't be thought of full, updated, and is not meant to
  be used rather than a visit, session, or recommendation of a authorized, medical, or some other
  skilled. • Advise feminine of childbearing age to make use of barrier contraceptives.
  
  There is an rising pattern toward testosterone supplementation in these ladies.
  
  Does the diminution that age brings with it in both whole and bioavailable T
  have any scientific significance? This query leads us to the theme of this paper, "The Many Faces of Testosterone".
  Much Less clear, or no less than more controversial,
  is the necessity of treating the gentler discount of
  testosterone seen within the growing older course of. SUMOylation of the androgen receptor occurs at two
  sites Lysine residues 388 and 521, however SUMOylation only at Lysine 388 results
  in a significant reduction of transcriptional activity (177).
  Nevertheless, latest, entire genome evaluation revealed that SUMOylation regulated both receptor recruitment to DNA and goal gene choice (178).
  
  If you’re taking hormone replacement remedy, regular follow-up
  appointments with a healthcare supplier are
  necessary. To make a prognosis, a supplier will think about your particular indicators, signs and
  any blood take a look at results. Prescription testosterone treatments can be found as gels, skin patches, and intramuscular injections.
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  Monday, 21 July 2025 22:18

  The excellent news is that the majority males who are affected by Low T can restore their libido with the secure, straightforward,
  natural and handy low testosterone therapy offered at one of our LoveJoy Clinic locations.
  This might help you handle the signs of male menopause, permitting you to perform to the best of your capability nicely in to old age.
  Testosterone deficiency can due to this fact trigger a breakdown in bodily
  perform, often subtly, as a person advances in age.
  
  Whole testosterone ranges tend to say no about 1.6 p.c
  a year, and roughly 20 p.c of men over 60 have ranges that might qualify
  as low. These tests should be performed in the morning (typically between 7
  a.m. and 9 a.m.) when testosterone levels are at their peak.
  However, because of fluctuations in testosterone levels throughout the day, a quantity of exams could additionally be necessary to confirm your
  levels precisely. For many, low testosterone can be effectively managed and improved by way of focused life-style changes
  and, when essential, medical therapy. Gynecomastia,
  characterised by the enlargement of breast tissue
  in males, is a possible symptom of low testosterone.
  It happens when there’s an imbalance between the hormones estrogen and
  testosterone within the physique. Whereas gynecomastia can happen at any age, it’s most
  commonly seen in newborns, adolescents going via puberty, and older men.
  If a pituitary problem is the trigger, pituitary hormones can be given to help the
  physique make extra sperm and restore fertility.
  A pituitary tumor might have therapy with surgery, medication, radiation or alternative of other hormones.
  
  This useful resource is intended for informational and academic purposes only.
  It just isn't meant to offer analysis or be an different alternative to professional medical advice from a healthcare
  practitioner.
  As we age each progress hormone and testosterone
  decrease and muscle loss follows. Research have shown by way of testosterone remedy and eating a reduced-calorie food plan you'll have the ability to burn fat and enhance muscle
  mass (1, 2, four, 11, 12 , thirteen, 14). Studies to reply
  these questions are underneath means, but will
  in all probability be years before we all know the outcomes.
  In the meantime, do not neglect that testosterone replacement
  hasn't been conclusively shown to enhance any health condition other than testosterone deficiency and its symptoms.
  For males with low testosterone levels as measured by a blood take a
  look at who also have signs of low testosterone, the choice to
  take testosterone substitute is one to make along with
  your doctor. It has been advised that a 1% lower in testosterone level
  per year just isn't unusual for middle-aged (30 to 50 years old) and older males.
  Whereas this lower may not be noticeable in some men, others could expertise important modifications beginning of their middle-aged
  years or more generally at age 60 and above.
  You ought to go to a medical physician to obtain a correct prognosis and alleviate your symptoms as quickly
  as attainable. Secondary hypogonadism occurs when the testicular perform is preserved, however the pituitary gland no longer
  stimulates them into producing T. That’s as a end result of 80% of the estrogen in males is produced by the enzyme aromatase which converts testosterone.
  
  The case studies reveal that TRT does improve other symptoms
  of low T but didn't trigger hair regrowth. Some research suggest
  that low testosterone might need a adverse effect on sleep phases which
  is why its high quality deteriorates. Progressive continual fatigue
  is among the most typical non-specific indicators of low T.
  Testosterone might have an effect on temper and emotional state by modulating the GABA and serotonin receptors in the brain.
  It will doubtless cease sperm manufacturing and
  subsequently isn't administered to men making an attempt to begin a household.
  
  Some patients can even expertise pimples or oily skin, or male sample hair loss.
  
  Based Mostly on this assessment, your doctor will
  create a customised remedy plan with the proper medication and dosage tailored to
  your particular wants. If the initial test exhibits low
  testosterone levels, UK laws require a follow-up venous
  blood take a look at performed by a nurse or phlebotomist.
  "A lack of both power training and cardiovascular exercise can contribute to reduced testosterone," says Dr Huang,
  who additionally blames poor sleep. Components like excessive screen time and the ‘always-on’ nature
  of contemporary life interferes with restorative sleep, which in flip affects hormone levels," he explains. If you could have considerations about your testosterone levels, your first level of contact is often a general practitioner or nurse. If they believe you have hypogonadism, you may be referred to an endocrinologist who specialises in treating hormone-related conditions. Fat cells metabolize testosterone to estrogen, reducing testosterone ranges. Additionally, obesity reduces levels of intercourse hormone binding globulin (SHBG), a protein that carries testosterone in the blood.
  "These may embody decreased muscle mass, decreased bone density with
  the next risk of fractures, elevated probabilities
  of creating diabetes, and heart problems, infertility and despair," Baumgarten said. Testosterone helps regulate metabolism by selling the expansion and upkeep of lean muscle mass. When testosterone levels decline, muscle mass could decrease, leading to a lower in resting metabolic price. A lower metabolic rate means your physique burns fewer energy at rest, making weight acquire extra probably. Experiencing frequent anger outbursts and irritability is a typical manifestation of low testosterone ranges in males. When testosterone ranges are low, it can affect your temper and result in increased irritability and difficulty managing anger. These anger outbursts may be intense and should even result in relationship issues.
  This occurred when testosterone levels had been "castrate," which is beneath 50 ng/dL. Analysis suggests that as you age and your testosterone levels progressively drop, you would possibly also expertise a decrease within the dimension of your testicles. Both testosterone ranges and cognitive functions, significantly memory, decline with age. As a outcome, medical doctors have theorized that lower testosterone levels may contribute to affected memory. If you’re taking hormone substitute therapy, common follow-up appointments with a healthcare provider are necessary. Typically in primary hypogonadism testosterone levels are inside the regular range and gonadotropins are high. Your specialist will allow you to perceive should you want remedy, even with regular testosterone levels.
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  Nonetheless, studies reveal that kind 2 diabetes has a strong hereditary element.
  
  Thus, hypogonadal men who are genetically predisposed are rather more vulnerable to develop diabetes as a complication. Let’s
  start by diving into low testosterone symptoms to look out for in men. To
  offer you technically correct, evidence-based data,
  content revealed on the Everlywell blog is reviewed by credentialed professionals with expertise in medical and bioscience
  fields.
  Injectable testosterone has been around the longest and
  has the biggest body of research supporting its use.
  
  When you are feeling like you’ve run out of choices, there could be at all times testosterone therapy.
  It only makes sense to try and work with a doctor that is extremely trained in this
  remedy. Many males will have a drop in their testosterone after round
  30 years old.
  "What is more frequent is the pure variation in testosterone necessities between people – each men and women," says Dr Foster.
  "There is rising interest within the role of genetics in testosterone manufacturing and the way the physique responds to it. At Present, there is not any evidence that testosterone ranges enhance when girls exercise.
  Without enough testosterone, blood could not be in a position to enter the penis and permit it to get inflexible sufficient for sex. It’s essential to notice scorching flashes occurred throughout prostate most cancers therapy. Hold studying to learn extra in regards to the signs, causes, and treatments for low testosterone. And other studies have estimated that more than 8% of men aged 50 to seventy nine years have low testosterone. It’s difficult for researchers to estimate how common low testosterone is since totally different studies have different definitions for low testosterone. Testosterone regulates fat metabolism by exerting catabolic results on adipose tissue and stimulating the metabolic price. Long-term hypogonadism if left untreated can lead to additional indicators corresponding to osteoporosis, anemia, and coronary heart issues.
  Men have additionally reported some much less widespread symptoms like a decline in physique hair and sizzling flashes. If you're experiencing any of these signs, consider getting your testosterone levels examined. You might have low testosterone if you’re experiencing a discount in your intercourse drive, problem attaining or maintaining an erection, hair loss, and fatigue. A doctor can conduct checks, such as a serum testosterone test, to diagnose low testosterone. They can also suggest extra exams to rule out different circumstances. If you’re experiencing signs of low testosterone, corresponding to a lower in sex drive and sizzling flashes, discuss to a healthcare supplier.
  Early analysis and remedy in males offer higher protection towards osteoporosis and other associated situations. Make certain to check with a healthcare supplier earlier than beginning a brand new supplement or treatment. One Other explanation for secondary acquired hypogonadism is kind 2 diabetes. Type 2 diabetes has been on the rise in current times with approximately 1 in 10 individuals identified with the condition.
  "We’re now seeing growing evidence also linking TD with despair, metabolic syndrome and reduced lifespan if left untreated.
  "Testosterone deficiency stays one of many least mentioned and most under-recognised and under-treated conditions affecting men’s health," Dr El-Osta explains.
  
  There is no clear proof that testosterone remedy is useful in reversing any elements of pure aging in males.
  Nonetheless, it's crucial to consult with a healthcare professional who can verify this
  by way of applicable tests. A specific amount of testosterone
  may be necessary for wholesome arteries because it's transformed into estrogen, which
  protects arteries from damage. As yet, no research present that testosterone substitute protects
  the center or prevents coronary heart assaults.
  At KashMD, Dr. Kash Sarabi conducts an intensive analysis to
  determine the foundation cause of your signs and develop
  an efficient remedy plan. Low testosterone can impair cognitive function, making it harder to
  focus, remedy problems, or recall data. This mental shift isn’t just irritating; it may possibly influence work efficiency and personal pursuits
  alike. Think About forgetting necessary dates more often or finding
  advanced tasks overwhelming after they used to be manageable.
  
  Males may find it tougher to pay attention or bear in mind issues – a symptom generally known as reduced psychological acuity.
  They may wrestle with tasks that require focus, like planning,
  decision-making, or problem-solving.
  To successfully manage anger outbursts caused by low testosterone,
  it’s essential to seek medical recommendation and
  remedy. Consulting with a medical skilled who specialises in hormone therapies, similar
  to testosterone substitute remedy, might help restore hormone levels and
  improve your temper. This can have a significant impact on decreasing anger
  outbursts and enhancing your general well-being.
  Feeling somewhat "meh" at times is part of being human—but
  if you’ve been stuck in a funk for a while, testosterone might be
  a factor. This hormone can affect mood and drive, so significant irritability,
  mood swings, or general lack of motivation might sign an imbalance.
  There are also finger prick blood tests available
  that you are capable of do at residence to get a sign of your
  testosterone stage. NHS GPs will probably refer you to
  an endocrinologist if yours is low. Testosterone therapy
  is accepted as a therapy for hypogonadism, a clearly outlined medical situation.
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